Narayana Translation Research and Incubation Centre (NTIC)



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SHIVA KUMAR

Dr. Sivakumar Vijayaraghavalu,

Professor and Head, NTRC

E-mail – drvshiva@narayanamedicalcollege.com

Office – 0861-2355511 extn 2406; Mobile – 8925744196;

VISION

To evolve as an International Centre of Excellence in Translational and Clinical Research

MISSION

  • To play an essential role in the Narayana Medical College in the training of Medical and Allied Medical Students, Residents, Clinical Fellows and Young Faculties in performing Clinical and Translational Research.
  • To initiate collaboration between clinicians and scientists to promote basic, clinical and translational research that eventually develops healthy society.
  • To be an academic breeding ground for budding researchers from other Medical- and Science- institutions to carry out their innovative pre-clinical and clinical research projects.
  • To facilitate the scientific interactions between different Departments of Medicine and its allied faculties to generate novel ideas and evaluate it scientifically.
  • To provide infrastructure and state-of-art technology to test the hypothesis that could result in an invention.
  • To help medical researchers to obtain intra- and extra-mural research grants to carry out their research and publish their research findings in high impact scientific journals.

Narayana Translational Research Centre

NTRC (recognized by DSIR, Govt. of India) – is an advanced center established with a view to be at par with international standards in both pre-clinical and clinical research. The infrastructure of the facility is of world class with a built in area of 16,000 Sq.Ft. which includes – Clinical Research Division, Conference Room, four Biosafety level II clean rooms with laminar air flow type II- A in each room to carry out Stem Cell, Molecular biology and Genetic studies. A central Laboratory exists with state of art instruments such as Real- Time PCR, Ultra High Performance Liquid Chromatography (UHPLC), Flow Cytometer, Inverted Fluorescence Microscope, Nanodrop and Microbiology incubator and Laminar hood. As well equipped with necessary equipment’s including cooling centrifuges, refrigerators and freezers (-20 & -80 deg. C), Gel-documentation system and an IR Camera. Outcome of various research activities carried out in this centre were published in both national and international reputed journals.

NTRC – Clinical Research Division

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Bio-safety Level II Clean Room Facility

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NTRC – Basic Research Division

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CENTRAL RESEARCH ANIMAL FACILITY

Two storeyed Animal facility established in 1999 and utilized for experimental research in accordance with the CPCSEA guidelines of the Government of India. It fully air –conditioned and houses lab animals such as rats, mice, rabbits and guinea pigs. It facilitates the following activities – UG and PG pharmacy animal practical experiments; in-house medical and paramedical research; inter-institutional research and industrial research. Animal health and well-being is monitored daily by a veterinarian; and animals were well maintained and fed ad libitum by animal care-takers (24 h x 7 d)

NTRC – Preclinical Research Division

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MANPOWER

Sl. No Name Designation
1 Dr. Sivakumar Vijayaraghavalu Professor & HOD
2 Dr. K. Babu Rao Veterinarian
3 Mr. Vasanth Kumar Mohan Assistant Professor
4 Mr. K. Bhargav Ram Computer Assistant
5 Mr. V. Eswaraiah Lab Assistant
6 Mr. Rahamathulla Kaja Animal Care Staff
7 Mrs. Mabajan B Animal Care Staff
8 Mrs. S.K Bashera Sweeper – Animal House
9 Mrs. Karunya Alagala Sweeper – Research Lab and Clinical Division

INSTRUMENTS

Sl.no Name of the Instrument Model /Make
1 Flow Cytometer BD FACSCanto ll
2 UHPLC Thermo Scientific Ultimate 3000
3 Atomic Absorption Spectroscopy Shimadzu
4 Inverted fluorescence microscope Olympus U- LH100HG
5 RT-PCR Bio-Rad; CFX 96
6 Deep Freezers (-20 deg. C &  -80 deg. C ) LG & Terumo penpol DF80U 300L;
7  Laminar airflow type II A  and CO2  Incubators Thermo Fisher
8 Gel  Documentation Unit G-Box
9 UV Spectrophotometer Systronics
10 Nanodrop Thermo Fisher 2000
11 Microbiology hood and incubator Hitech; Technico
12 Hot air oven Yarko
13 Gel Dryer Thermocon
14 Trans-illuminator Lark LIUVT312
15 Flame Photometer Systronics 129
16 Autoclave Equitron
17 Muffle Furnace BTI Biotech
18 Humalyzer Human 300
19 Densitometer Systronics
20 Precision balances Systronics


RECENT PROJECTS

COVID -19 projects

1. Title – Clinical evaluation for the prophylactic role of traditional Siddha formulation Vishasura Kudineer enlisted in Advisory of Ministry of AYUSH for COVID-19.
Sponsor – Ministry of AYUSH, Government of India.
Status – Ongoing
PI – Dr. PrasannaPurna K, Co-PI’s – Dr. Sivakumar Vijayaraghavalu; Dr. R. Shailaja (Ayush Clinician).

2. Title – An Academic Multicenter Open label Single Arm Study to Record the Efficacy of Indomethacin among Confirmed COVID-19 patients with Mild and Moderate Symptoms.
Sponsor – IIT Madras, Chennai, India.
Status – Ongoing
PI – Dr.PrasannaPurna; Co-PI – Dr. Sivakumar Vijayaraghavalu; Project in collaboration with IIT Madras.

3. Title – An Academic Retrospective Study to Record the Efficacy of Paracetamol along with other drugs, among Confirmed COVID-19 patients with Mild and Moderate Symptoms.
Sponsor – IIT Madras, Chennai, India.
Status – Ongoing
PI – Dr. K. Prasanna Purna; Co-PI – Dr. Sivakumar Vijayaraghavalu; Project in collaboration with IIT Madras.

4. Title – Phase IV, Multi-Center, Open Lable, Clinical Trial to Assess the Safety and Efficacy of Remdesivir in Moderate to Severe SARS CoV2 Infection (COVID-19) in Indian patients.
Sponsor – Jubiliant Generics, CRO; JSS Medical Research India Pvt. Ltd.
Status – Study Site Approved
PI – Dr. Prasanna Purna, Co-PI – Dr. Ravi Teja,
Site Manager – Dr. Sivakumar Vijayaraghavalu, Coordinator Mr. Vasanth Kumar

5. Title – A Prospective, Open Label, Multicenter, Single Arm Phase Iv Study to Evaluate the Safety and Effectiveness of Avigan® (Favipiravir) Tablets 200 Mg as Add On to Standard Supportive Care in Adult Indian Patients with Mild to Moderate Covid-19 Disease- Project submitted and in evaluation process (likely to be approved)
Sponsor – Dr. Reddy’s Laboratory; CRO; JSS Medical Research India Pvt. Ltd.
PI – Dr. Chappadi Rajesh Reddy, Co-I Dr. PrasannaPurna
Site Manager – Dr. Sivakumar Vijayaraghavalu
Coordinator Mr. Vasanth Kumar

Non- COVID Projects

6. Title – Randomized, Parallel Group, Phase III Study to Compare Safety and Efficacy of BFLUID with a Commercially Available Solution, NUTRIFLEX PERI, as a Control Product in Patients Undergoing Gastrectomy or Colectomy
Sponsor – – Otsuka Pharmaceutical India Pvt Ltd; CRO – JSS Medical Research (MNC – Head-quarters Canada)
Status – Approved
PI – Dr. Thirunavukkarasu
Blinded Assesor-Dr. Gurudutt P. Varty
Clinical Site Manager – Dr. Sivakumar Vijayaraghavalu
Coordinator – Mr. Vasanth Kumar

RECENTLY ORGANIZED WEBINARS

1. Title – Scientific Writing & Searching Medical Databases 17/11/2020; 10 am to 11 am

Speaker
Dr. Ishima Badhwar, M.B.B. S, M. Tech, Clinical Consultant Elsevier, Head of Customer engagement division, Elsevier India and South Asia.

Registrants Profile-
Total two hundred and forty-four registrants were from India (95%) and other countries (5%) which includes – Bahrain, Sweden, Japan and Malaysia. Indian registrants were from across the country with higher percentage from Andhra Pradesh (75%), followed by Tamil Nadu (11%), and Telangana (9%); rest of the 2% are from the following states – Maharashtra, Karnataka, New Delhi and Haryana.

Reference Link-Scientific Writing and Searching Medical Databases | Narayana Medical COllege

2. Title – The International Webinar on PHD THESIS WRITING 10/09/2020; 10 am to 2 pm

Speakers
Dr. Venugopalan Cheriyath & Dr. Izhar A Khan, are Associate Professors from Dept. of Biological Sciences, Texas A&M University-Commerce, Texas, USA.

Registrants Profile-
Total Registrants –494, From India – 96%, Rest of the world 4% – from the following countries – United States of America (USA), Saudi Arabia, Oman, Qatar, Bahrain, Ethiopia, Malaysia and Japan. Distribution of registrants from different states of India is as follows – Andhra Pradesh (30%), Tamil Nadu (17%), Karnataka (14%), Puducherry (7%), Telangana (5%), Kerala (5%), rest 22% are from – Maharashtra, Uttar Pradesh, Punjab, Jharkhand, Rajasthan, Madhya Pradesh, West Bengal, Uttrakhand, Himachal Pradesh, Gujarat, Haryana and Odisha.

Reference Link-International Webinar on PhD Thesis Writing | Narayana Medical College Nellore

3. Title -Biosafety and Precaution Concerning Covid-19 18/08/2020; 2.30 pm to 5.00 pm

Speakers
I. Dr. Madhavi Dokur, Ph.D, Head of HSE, Shantha Biotechnics Pvt. Limited, (A Sanofi Company), Hyderabad, India.

II. Dr. Richa Arya, Ph.D, Assistant Professor, Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, India.

Registrants Profile-
Registrants – 548, out of it 532 are from India (97.1%), rest are from the following countries – United States of America (USA), United Kingdom (UK), Germany, Japan and Saudi Arabia. Distribution of registrants from different states of India is as follows – Andhra Pradesh (81%), Tamil Nadu (14%), Karnataka (3%), rest 2% are from – Maharashtra, Telangana, Uttar Pradesh, Punjab, Jharkhand, Rajasthan and Kerala.

Reference Link-minutes of biosafety | Narayana Medical College

4. Title – International Webinar on Therapeutic Applications of Human Induced Pluripotent Stem Cells 4/8/2020; 10 am to 11 am.

Speaker –
Dr. Narasimman Gurusamy, University of Tennessee Health Science Centre (UTHSC), Memphis, Tennessee (TN), USA.

Registrants Profile-
Registrants – 539 out of it 529 are from India (98%), rest are from the following countries – United States of America (USA), Japan and Saudi Arabia. Distribution of registrants from different states of India is as follows – Andhra Pradesh (95%), Tamil Nadu (2%), Kerala (2%), rest are from – Maharashtra, Telangana, Uttar Pradesh, Karnataka and Uttarakhand.

Reference Link-therapeutic applications of human induced pluripotent stem cells

5. Title – International Webinar on Computerized Assessment & Blended Learning in Medical Education 20/7/2020; 10.30 am to 1 pm

Speakers
I. Dr. Noohu Abdullah Khan, Assistant Professor, Clinical Pharmacy, King Khalid University, Kingdom of Saudi Arabia.
II. Dr. Ayyub Ali Patel, Assistant Professor, Dept. of Biochemistry, College of Medicine, King Khalid University, Kingdom of Saudi Arabia.

Registrants Profile-
Total Four Hundred and Thirty-two (432) registrants; Indian registrants – 98%, foreign nationals -2% from USA, Oman and Saudi Arabia. Indian registrants are from the following states – Andhra Pradesh (69%), Tamil Nadu (20%), Maharashtra (4%), Karnataka (2%) and rest 2% are from Telangana and Kerala.

Reference Link-international webinar on computerised assessment blended learning in medical education/